Abstract
Modification of the non-nucleoside inhibitor of HIV-1 reverse transcriptase nevirapine (Viramune) by incorporation of a 2-indolyl substituent confers activity against several mutant forms of the enzyme.
MeSH terms
-
Anti-HIV Agents / chemistry
-
Anti-HIV Agents / pharmacology
-
Cell Line
-
HIV Reverse Transcriptase / antagonists & inhibitors*
-
Humans
-
Magnetic Resonance Spectroscopy
-
Nevirapine
-
Pyridines / chemistry
-
Pyridines / pharmacology*
-
Reverse Transcriptase Inhibitors / chemistry
-
Reverse Transcriptase Inhibitors / pharmacology*
Substances
-
Anti-HIV Agents
-
Pyridines
-
Reverse Transcriptase Inhibitors
-
Nevirapine
-
HIV Reverse Transcriptase